Students examine basic concepts of toxicology as they apply to the effects of environmental agents, e.g. chemicals, metals, on public health. We discuss the distribution, cellular penetration, metabolic conversion, and elimination of toxic agents, as well as the fundamental laws governing the interaction of foreign chemicals with biological systems. Students focus on the application of these concepts to the understanding and prevention of morbidity and mortality resulting from environmental exposures to toxic substances through a case study format.
Upon successfully completing this course, students will be able to:
Student evaluation is based on:
Introduction to Online Learning; a background in college biochemistry and cell biology strongly encouraged.
All students are expected to have thoroughly reviewed the “Student Handbook on Referencing” available on the student portal and in the On-line Library in the General Folder.
This course has two primary goals:
The first goal will be accomplished in Modules 1–2 (Lectures 1–7) by presenting lectures emphasizing the principles of chemical distribution, cellular penetration, metabolism, and elimination. Additional topics covered in these lectures will include the mechanisms of carcinogenesis by environmental agents, cancer biomarkers and susceptibility factors, approaches to monitoring exposures to xenobiotics, dose-response relationships, toxicity testing, and risk assessment.
The second course goal will be accomplished in Module 3 (Lectures 8–16) by the presentation of case studies. The case studies are designed to further develop and illustrate the basic principles and mechanisms of toxicology as applied to various chemicals or classes of chemicals in selected tissues and organs.
Course content is divided into two modules. Within each module are individual lectures, which are presented sequentially and should be completed in that order. Lectures combine audio presentation and slides—just like attending lectures in class. You may return to any previous lecture at any point and review its contents at your convenience.
On each lecture's main page, you will find a listing of the section topics, links to the lecture materials, a listing of reading assignments, and links to Web resources. You'll also find any required course work.
We strongly encourage you to initiate and participate in bulletin board discussions with your fellow students. However, you will not be graded on your participation in these discussions.
Each lecture has assigned readings from the textbook and also an assigned paper(s). We recommend reading the pages in the text prior to listening to the lecture and reading the assigned paper(s) after listening to the lecture. The assigned papers are posted in E-reserves.
Students enrolled in the Bloomberg School of Public Health of The Johns Hopkins University assume an obligation to conduct themselves in a manner appropriate to the University's mission as an institution of higher education. A student is obligated to refrain from acts which he or she knows, or under the circumstances has reason to know, impair the academic integrity of the University. Violations of academic integrity include, but are not limited to: cheating; plagiarism; knowingly furnishing false information to any agent of the University for inclusion in the academic record; violation of the rights and welfare of animal or human subjects in research; and misconduct as a member of either School or University committees or recognized groups or organizations.
Students should be familiar with the policies and procedures specified under Policy and Procedure Manual Student-01 (Academic Ethics), available on the school’s http://my.jhsph.edu portal.
The faculty, staff and students of the Bloomberg School of Public Health and the Johns Hopkins University have the shared responsibility to conduct themselves in a manner that upholds the law and respects the rights of others. Students enrolled in the School are subject to the Student Conduct Code (detailed in Policy and Procedure Manual Student-06) and assume an obligation to conduct themselves in a manner which upholds the law and respects the rights of others. They are responsible for maintaining the academic integrity of the institution and for preserving an environment conducive to the safe pursuit of the School's educational, research, and professional practice missions.
There will be two closed-book examinations for this course. The first will be the midterm examination, and the second will be the final examination. Exams will consist of multiple-choice, fill-in-the-blank, and short-essay/problem questions. The other components of the final grade will be two written assignments and 7 quizzes. The grading will be determined as follows:
Midterm: 100 points
Final: 100 points
Weekly quizzes: 84 points (7 quizzes; each worth 12 points)
Assignment 1: up to 30 points
Assignment 2: up to 50 points
Total points possible: 364
Assignments: Descriptions of the assignments can be found in the Online Library in the Assignments Folder. The assignments must be completed on your own.
Quizzes: There will be 7 online quizzes and each will comprise of 6 questions at 2 points each. The quizzes are open-book, but you are to complete them on your own. You will have to study ahead of time because once you begin the quiz, you will have 20 minutes to enter your answer. This may not give you sufficient time to page through your notes or the slides or the assigned reading to find the answer.
Midterm: The midterm is a closed-book examination covering lecture materials 1-7. The exam will be online using the Quiz Generator. A proctor system will be used to administer the examination, which will be the same as a classroom examination. You will work on the examination alone, without aids.
Final: The final examination is a closed-book comprehensive examination of all the course material. It will be administered online using the Quiz Generator. A proctor system will be used to administer the examination, which will be the same as a classroom examination. You will work on the examination alone, without aids.
Final grade: The final grade will be determined based on the number of points achieved by summing the total points on these five components versus the total number of points possible and determining a final grading scale, as follows:
A = 90-100% of total points
B = 80-89% of total points
C = 70-79% of total points
D = 60-69% of total points
F = <60%
The final grading scale may be curved at the discretion of the faculty.
Technical concerns about the functionality and operation of course Web pages (before emailing, please make sure that you can replicate the problem)
Technical help with JHSPH email or desktop applications
The most recent student evaluations for this course indicate that successfully
completing the course involved a range of time commitments, as follows:
Step 1: Select a professional person as your proctor—a work supervisor, for example, or a librarian, a member of clergy, etc.—following the specified proctored exam guidelines. Confirm your proctor’s willingness and ability to proctor the exams for you on the approved testing dates, which are indicated on the course schedule next to the exam listings. Then complete and submit the proctor selection form on the guidelines page. You must submit this form no later than the due date indicated on the course schedule. You must have access to an Internet-enabled computer on which to take your exams in the presence of your proctor.
Step 2:. Your proctor will receive an email from the course approximately one week before the earliest approved testing date (indicated on the course schedule next to the exam listing) with the password he/she will need to enter in order for you to access the exams. Confirm that your proctor has received the password no later than two days before your scheduled exam date. You will also receive an email at that time informing him/her that a password has been sent to your proctor. You should contact the course instructor/TAs immediately if the proctor has not received the password or if there are any questions about how to access the exams. Your selected proctor will enter a password into the online Quiz Generator to allow you access to the exam and remain present while you complete the exam. Once you have access to the exams, you will have 90 minutes to complete the exam online
Step 3: Take the exams on your selected date, following the specific instructions included in the exams. You will have an hour and a half to take both the midterm and final exams.
For these exams, it is your responsibility to: