Welcome to the CoursePlus Web site for TOXICOLOGY: THE MOLECULAR BASIS (187.632.01), a course offered by the Department of Environmental Health Sciences at the Johns Hopkins Bloomberg School of Public Health.
Reviews the mechanisms of environmental toxicology at the molecular and genetic levels through faculty lectures and discussion of scientific papers. Topics include cell signaling pathways involved in protection from environmental insults, including the stress responses to heat shock, oxidative damage and exposure to toxic metals and xenobiotics. Addresses the impact of environmental agents on cell growth, cell death and the multi-stages of carcinogenesis. Presents most recent technological advances in the molecular and genetic tools available to study problems of environmental toxicology, which includes bioinformatics, genomic arrays and transgenic animals.
After successfully completing this course, you will be able to do the following: * Analyze and understand the literature regarding a wide array of topics relevant to molecular toxicology, including the molecular response to environmental stress and pathways of carcinogenesis and DNA repair. * Describe various gene-environment interactions that lead to either cell adaptation, cell death or disease in response to toxins in the environment. * Understand the application of various state-of-the-art techniques for molecular analyses, including proteomics, genomics, bioremediation, surface plasma resonance, transgenic animals for research and polymorphism monitoring.
Mon Wed Fri 10:30 AM to 11:50 AM
187.610 and a basic course in molecular biology or consent of instructor.
students interested in toxicology at the molecular and genetic levels
Grading Policy: Student evaluation based on class participation and a final exam.
Grading Restrictions: Letter grade