About The CourseWelcome to the CoursePlus Web site for PRINCIPLES OF IMMUNOLOGY I (260.611.01), a course offered by the Department of Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health.
Introduces biological concepts of immunology; molecular nature of antigens; molecular basis for antibody and T-cell receptor structure and diversity; complement; hypersensitivity reactions; cellular basis for the immune response; cell-mediated immunity; adhesion molecules and coreceptors cell activation; cytokines and other soluble mediators; major histocompatibility complex (MHC) antigens; tumor immunology; transplantation immunobiology; mechanisms of resistance to microorganisms; tolerance; autoimmunity; and immuno-deficiency.
Upon successfully completing this course, students will be able to:
- Define the tissue, cellular and molecular components that constitute the vertebrate innate and adaptive immune system
- Explain the generation of lymphocyte antigen receptors and the molecular and cellular basis for diversity and specificity of receptors on immune cells
- Define the basis for antigen presentation to T cells
- Define the basis for recognition of self and non-self recognition
- Define the development and survival of lymphocytes
- Explain the major signaling pathways used by immune cells
- Define T cell-mediated and B cell-mediated immunity
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