Welcome to the CoursePlus Web site for ENVIRONMENTAL HEALTH: THE MOLECULAR BASIS (187.632.01), a course offered by the Department of Environmental Health Sciences at the Johns Hopkins Bloomberg School of Public Health.
Reviews the mechanisms of environmental diseases at the molecular and genetic levels through faculty lectures and discussion of scientific papers. Presents most recent technological advances in the molecular and genetic tools available to study environmental diseases, which includes omics technologies (proteomics, genomics and metabolomics), microarray, nextgen sequencing for genetic variations (SNPs), bioinformatics, transgenic animals and emerging alternative animal models. Topics include mechanisms and cell signaling pathways involved in oxidative, nitrosative stress and inflammation in response to exposure to air pollutants, metals and other environmental toxicants that causes non-communicable diseases such as cancer, lung and heart diseases. Addresses the impact of environmental toxicants on cell growth, cell death, DNA repair, epigenetics, inflammation and the multi-stages of carcinogenesis which cause major non-communicable diseases and impact public health.
Upon successfully completing this course, students will be able to:
- Analyze and Discuss the literature regarding a wide array of topics relevant to molecular toxicology, including the molecular response to environmental stress and pathways of carcinogenesis and DNA repair
- Describe various gene-environment interactions that lead to either cell adaptation, cell death or disease in response to toxins in the environment
- Discuss the application of various state-of-the-art techniques for molecular analyses, including proteomics, genomics, bioremediation, surface plasma resonance, transgenic animals for research and polymorphism monitoring
Mon Wed Fri 10:30 AM to 11:50 AM
187.610 and a basic course in molecular biology or consent of instructor.
students interested in toxicology at the molecular and genetic levels
Grading Policy: Total grade will be based on midterm and final exams and attendance.
Grading Restrictions: Letter grade