About The CourseWelcome to the CoursePlus Web site for GENOMICS FOR PUBLIC HEALTH (120.608.01), a course offered by the Department of Biochemistry and Molecular Biology at the Johns Hopkins Bloomberg School of Public Health.
Introduces genomics and modern genetic technologies, emphasizing their application to significant public health problems, to students who have limited prior coursework in molecular biology or molecular genetics. Integrates lectures and discussions with computer exercises in laboratory sessions. Topics include fundamental principles of molecular biology; genome sequencing and structure; gene cloning; mapping of human disease genes; use of DNA microarrays, protein microarrays, and next generation rapid DNA sequencing methodologies in analysis and treatment of human disease; comparative genomics of model and pathogenic organisms; epigenomics and metagenomics; and genetically modified organisms.
Upon successfully completing this course, students will be able to:
- Describe the organization of the human genome and the genomes of selected model organisms
- Explain how human disease genes are mapped
- Analyze DNA, RNA, or protein sequences through the use of public domain databases and algorithms
- Explain how DNA microarrays, protein microarrays, and rapid whole-genome-sequencing technologies can be used to analyze or treat human disease in individuals and populations
- Describe basic recombinant DNA, proteomic, and biotechnological methodologies used in the analysis of human disease
- Explain how modifications to chromatin or the presence of gut microbial flora impact expression of selected human genes.
Roger McMacken
E-mail: rmcmacke@jhsph.edu
Terry Brown
E-mail: tbrown@jhsph.edu
Randy Bryant
E-mail: fbryant@jhsph.edu
Daniela Drummond-Barbosa
E-mail: dbarbosa@jhsph.edu
P.C. Huang
E-mail: pchuang@jhsph.edu
MPH students, students in the genetic epidemiology program, and all graduate students interested in learning about the application of genomics and modern genetic technologies to human disease and to specific public health concerns. This is an introductory course and is not intended for advanced PhD students in the laboratory sciences.
Grading Policy: Student evaluation based on four online quizzes (1/4 of total), two computer lab exercises (1/4 of total) and a final exam (1/2 of total).
Grading Restrictions: Letter grade
Roger McMacken
E-mail: rmcmacken@jhsph.edu
P.C. Huang
E-mail: pchuang@jhsph.edu
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