Welcome to the CoursePlus Web site for GENOME INTEGRITY AND CANCER (120.624.01), a course offered by the Department of Biochemistry and Molecular Biology at the Johns Hopkins Bloomberg School of Public Health.
Examines molecular mechanisms devoted to the preservation of genome integrity eukaryotic cells. Topics include DNA damage recognition, DNA repair pathways, cell cycle checkpoint mechanisms, the role of p53 in DNA damage responses, the role of ubiquitination and sumoylation in DNA repair, telomere maintenance and DNA repair proteins as target for therapeutic intervention. Emphasizes the relevance of these mechanisms for human cancer.
This course will prepare you to be able to do the following:
- Understand how exposure to various environmental agents and anti-cancer drugs can lead to modifications of DNA
- Understand the mechanisms by which DNA repair proteins and enzymes maintain the integrity of the genome
- Understand how DNA protection and repair systems function in the context of the cell
- Understand the connections between DNA damage/DNA repair capacity and human disease, particularly cancer
Mon Wed 3:30 PM to 4:50 PM
Graduate level molecular biology, and biochemistry or the equivalent.
MHS and PhD students interested in the biomedical sciences
Grading Policy: Two in-class exams.
Grading Restrictions: Letter grade