About The Course
Welcome Message

Welcome to the CoursePlus Web site for GENOME INTEGRITY AND CANCER (120.624.01), a course offered by the Department of Biochemistry and Molecular Biology at the Johns Hopkins Bloomberg School of Public Health.

Course Description

Examines molecular mechanisms devoted to the preservation of genome integrity eukaryotic cells. Topics include DNA damage recognition, DNA repair pathways, cell cycle checkpoint mechanisms, the role of p53 in DNA damage responses, the role of ubiquitination and sumoylation in DNA repair, telomere maintenance and DNA repair proteins as target for therapeutic intervention. Emphasizes the relevance of these mechanisms for human cancer.

Course Learning Objectives

This course will prepare you to be able to do the following:

  • Understand how exposure to various environmental agents and anti-cancer drugs can lead to modifications of DNA
  • Understand the mechanisms by which DNA repair proteins and enzymes maintain the integrity of the genome
  • Understand how DNA protection and repair systems function in the context of the cell
  • Understand the connections between DNA damage/DNA repair capacity and human disease, particularly cancer

Course Time

Mon Wed   3:30 PM to 4:50 PM

Course Faculty

Graduate level molecular biology, and biochemistry or the equivalent.

Intended Audience

MHS and PhD students interested in the biomedical sciences

Grading Policy & Grading Restrictions

Grading Policy: Two in-class exams.

Grading Restrictions: Letter grade

Administrative Contact

Paul Miller
E-mail: pmiller@jhsph.edu