PUBLIC HEALTH TOXICOLOGY Syllabus

187.610.01 | AY 2012-2013 - 1st Term | 4 Credit(s)
WF 3:30:00 PM
  • Contact Information
    Faculty
    Michael Trush
    James Yager
  • Course Learning Objectives

    Information not required for this course type

  • Course Description
    Students examine basic concepts of toxicology as they apply to the effects of environmental agents, e.g. chemicals, metals, on public health. We discuss the distribution, cellular penetration, metabolic conversion, and elimination of toxic agents, as well as the fundamental laws governing the interaction of foreign chemicals with biological systems. Students focus on the application of these concepts to the understanding and prevention of morbidity and mortality resulting from environmental exposures to toxic substances through a case study format.

    Additional Faculty Notes:

    Fot two lectures, Hepato and Renal Toxicology and Reproductive and Developmental Toxicology, students are assigned to listen to an on-line module that describes the basic structures, functions and toxic responses of these systems before coming to the lectures which will focus on the case studies.

  • Intended Audience
    The course is intended for students in professional degree programs who wish to gain a broad understanding of the basic concepts and principles of toxicology. It also serves as an introductory course for those students in academic degree programs who are planning on following a course of more advanced study in the science of toxicology.

    Additional Faculty Notes:

    The course is intended for students in professional degree programs who wish to gain a broad understanding of the basic concepts and principles of toxicology. It also serves as an introductory course for those students in academic degree programs who are planning on following a course of more advanced study in the science of toxicology.

  • Methods of Assessment
    Student evaluation is based on weekly on-line quizzes, two individual written assignments and one group written assignment completed using a Wiki, a midterm and final exam.

    Additional Faculty Notes:

    Student evaluation is based on weekly on-line quizzes, two individual written assignments and one group written assignment completed using a Wiki, a midterm and final exam.

    Grades will be determined as follows: Midterm Exam: 100 points; Final Exam: 100 points; Weekly Quizzes:  60 points (6 quizzes, each with 5 questions at 2 points each); Assignment 1: 30 points; Assignment 2: 50 points; Assignment 3:  20 points

    Total Points Possible: 360

    Final grade: The total number of possible points will be 360. The final grade will be determined based on the number of points achieved by summing the total points on the exams, quizzes and assignments versus the total number of points possible (360) and determining a final grading scale: >90%of total points= A; 89-80%=B; 79-70%=C; 69-60% =D; <59%=F .The final grading scale may be curved at the discretion of the faculty.

  • Prerequisites
    Background in chemistry (particularly organic chemistry) and biology useful.

    Additional Faculty Notes:
    Background in chemistry (particularly organic chemistry) and biology is useful, but not necessary.

  • Required Text(s)

    Additional Faculty Notes:

    A text book is not used in this course

    References Textbooks that may be helpful for obtaining more detail on various topics covered in lectures (not required):

     Casarett and Doull’s ToxicologyThe Basic Science of Poisons, 7th Edition, C.D. Klaassen (ed.), McGraw-Hill Medical, NY, 2008. (Older editions also contain basic information that may be helpful)

    Principles and Methods of Toxicology. 5th Edition. A. Wallace Hayes (ed). CRC Press, Boca Ratan, 2008. (Older editions also contain basic information that may be helpful)

     

     

     

  • Course Schedule

    Please see the course Session for a full list of dates and items for this course.

  • Academic Ethics Code

    Students enrolled in the Bloomberg School of Public Health of The Johns Hopkins University assume an obligation to conduct themselves in a manner appropriate to the University's mission as an institution of higher education. A student is obligated to refrain from acts which he or she knows, or under the circumstances has reason to know, impair the academic integrity of the University. Violations of academic integrity include, but are not limited to: cheating; plagiarism; knowingly furnishing false information to any agent of the University for inclusion in the academic record; violation of the rights and welfare of animal or human subjects in research; and misconduct as a member of either School or University committees or recognized groups or organizations.

  • Welcome Message

    Welcome to Public Health Toxicolgy.  Virtually each day you can read in the paper about the effects of various chemicals in the environment and in the diet on human health. Most of the articles speak of adverse effects observed in recent scientific investigations. However, it is often very difficult to critically evaluate the real potential significance of this information. In this course, you will learn the basic principles that govern how chemicals interact with cells and organisms to cause adverse effects and what the critical determinants are that determine whether or not an adverse effect might occur. This will provide you with new tools to help interpret the barrage of information presented to you in the lay press and should be helpful in your professional activities. We sincerely hope you enjoy this course and find the information useful. We also appreciate your input and suggestions as to how to improve the course, so please be sure to complete the course evaluation and don't hesitate provide us with any constructive comments or suggestions you may have by e-mail or in person. Thank you.

  • Course topics

    Basic Principles: Factors that Affect Toxicity - Absorption, Distribution, Excretion, and Biotransformation; Applied Toxicology & Case Studies - Approaches to Primary and Secondary Prevention; Environmental Carcinogenesis, Biomarkers of Exposure and Susceptibility Factors;  Toxicity Testing (Hazard Assessment: Toxicity Testing In Vivo & In Vitro), Dose Response and the Risk Assessment  Process; Persistent Organic Pollutants (POPs) and Dioxins;  Hepato and Renal Toxicology -  Basic Principles and specific examples (e.g. Ethanol, Carbon Tetrachloride, Chloroform);  Reproductive & Developmental Toxicology - Basic Principles and specific examples (e.g. Endocrine Disruptors, Thalidomide)'  Metal Toxicology - Overview of Metal Toxicology and specific examples (e.g. Mercury, Cadmium); Neurotoxicology;  Immunotoxicology - Basic Principles, Cutaneous & Pulmonary Hypersensitivity;  Air Toxicants: Ozone and Benzene; Nanoparticle Toxicology.

  • Contact Information(from old syllabus)

    James Yager, Ph.D.
    Email: jyager@jhsph.edu
    Office: E7539
    Tel: 410-955-3348

    Michael Trush, PhD
    Email: mtrush@jhsph.edu
    Office: E7537

    James Yager
    Email: jyager@jhsph.edu
    Office: W1513
    Tel: 5-3348

    Michael Trush
    Email: mtrush@jhsph.edu
    Office: E7537
    Tel: 410-955-2973

  • Course Objectives(from old syllabus)

    This course has two primary objectives: (1) to introduce you to the underlying principles governing the interactions of foreign chemicals (xenobiotics) with biological systems and (2) to develop an understanding of the kinds of toxic manifestations which can occur as a result of chemico-biological interactions.  The first objective will be accomplished in lectures emphasizing the principles of chemical distribution, cellular penetration, metabolism and elimination.  Additional topics covered in these lectures will include the mechanisms of carcinogenesis by environmental agents, biomarkers and susceptibility factors, approaches to monitoring exposures to xenobiotics, dose-response relationships, toxicity testing  and risk assessment, approaches to primary and secondary prevention in toxicology . The second course objective will be accomplished by the presentation of case studies lectures. The case studies are designed to further develop and illustrate the basic principles and mechanisms of toxicology as applied to various chemicals or classes of chemicals in selected tissues and organs. These case studies cover the effects of environmental chemicals and metals on lung, liver, kidney, reproductive tissue, development, bone marrow and the brain.

     

  • Disability Support Services
    If you are a student with a documented disability who requires an academic accommodation, please contact the Office of Student Life Services at 410-955-3034 or via email at dss@jhsph.edu.