260.623.01 | AY 2012-2013 - 1st Term | 4 Credit(s)
MWF 3:30:00 PM
  • Contact Information
    Diane Griffin
  • Course Learning Objectives

    Upon successfully completing this course, students will be able to:

    • Discuss basic mechanisms of animal virus replication
    • Discuss basic cellular and host responses to viral infection
    • Become familiar with the major virus families that cause human disease
    • Discuss the mechanisms by which viruses in these families cause disease
    • Discuss how viruses in these families are transmitted and maintained in populations
  • Course Description
    Discusses cellular, molecular, genetic, and immunological principles that govern viral infection. Presents a survey of main virus groups with detailed discussion of several representative human pathogens. Topics include replication strategies, pathogenesis, carcinogenesis, vaccination, and the use of viruses as tools in molecular and cell biology. Emphasizes interactions of viral and host cell processes.
  • Methods of Assessment
    Student evaluation based on a mid-term and a final examination.

    Additional Faculty Notes:
    Final grades are based on a basic facts quiz (15%), a mid-term examination (35%) and a final examination (50%).

  • Prerequisites

    Additional Faculty Notes:
    Lectures - MWF 3:30-4:50 pm        Bloomberg School of Public Health Room W4030

  • Required Text(s)

    Additional Faculty Notes:

    Primary Text

    • Principles of Virology, by Flint, Enquist, Krug et al, 3rd ed., ASM Press, 2009

    Additional texts of interest

  • Course Schedule

    Please see the course Session for a full list of dates and items for this course.

  • Academic Ethics Code

    Students enrolled in the Bloomberg School of Public Health of The Johns Hopkins University assume an obligation to conduct themselves in a manner appropriate to the University's mission as an institution of higher education. A student is obligated to refrain from acts which he or she knows, or under the circumstances has reason to know, impair the academic integrity of the University. Violations of academic integrity include, but are not limited to: cheating; plagiarism; knowingly furnishing false information to any agent of the University for inclusion in the academic record; violation of the rights and welfare of animal or human subjects in research; and misconduct as a member of either School or University committees or recognized groups or organizations.

  • Course topics
    • Section 1. Introduction to Virology History, taxonomy, structure and evolution Multiplication, virus assay and genetics
    • Section 2. Virus Replication Receptors, fusion and entry Trafficking and processing of viral proteins Modification of host cell function Virus assembly and exit
    • Section 3. Virus-Host Interactions Immune responses/innate Immune responses/adaptive Pathogenesis/ virulence and attenuation
    • Section 4. Plus-strand and DS RNA Viruses Replication of plus strand RNA viruses Picornaviruses Togaviruses and Flaviviruses Rotaviruses and Caliciviruses
    • Section 5. Negative-strand RNA Viruses and Retroviruses Replication of negative strand RNA viruses Orthomyxoviruses Paramyxoviruses Retroviruses
    • Section 6. DNA Viruses and Viral Oncogenesis Replication of DNA viruses Adenoviruses Herpesviruses Viral oncogenesis
  • Contact Information(from old syllabus)

    Andrew Pekosz, PhD
    Office: E5635
    Tel: 410-502-9306
    Home Page:

    Robert Buckheit, BS

    Matthew Cousins, MS
    Office: Ross 646

    Diane E. Griffin, MD, PhD
    Office: 615 North Wolfe Street, Suite- E5132
    Tel: 410-955-3459
    Home Page:

    Janice Clements, Ph.D.
    Office: BRB 839
    Tel: 410-955-9770
    Home Page:

  • Disability Support Services
    If you are a student with a documented disability who requires an academic accommodation, please contact the Office of Student Life Services at 410-955-3034 or via email at