120.603.01 | AY 2012-2013 - 2nd Term | 3 Credit(s)
TTh 2:00:00 PM
  • Contact Information
  • Course Learning Objectives

    Upon successfully completing this course, students will be able to:

    • Describe modern molecular biology techniques
    • Explain how these techniques can be applied to a major public health problem
    • Interpret data generated by these techniques
    • Describe the molecular basis for the pathogenesis of specific strains of influenza
    • Read and present original papers in this area
  • Course Description

    Explores how molecular biology has been used to define the biological basis of a public health catastrophe, the 1918 Spanish Influenza Pandemic. Students examine the biological basis of the virulence of more recent influenza viruses. Topics include: use of molecular techniques to resurrect the extinct 1918 pandemic virus, the use of molecular techniques to identify why specific mutations in the genome made the 1918 virus so virulent, the use of sequence analysis to identify the origin of new strains of influenza virus, and the analysis of the immune response of an infected host to the 1918 virus. Students also examine the molecular biology of the more recent H1N1 pandemic and the H5N1 bird flu viruses. Students discuss ethical and policy issues that must be considered in managing the response to a pandemic.

  • Intended Audience

    Graduate students who are interested in learning about the molecular biology of influenza and/or are interested in the application of molecular biology to major public health problems.

  • Methods of Assessment

    Grading Policy: Evaluations of oral presentations by students and a midterm and final examination.

    Grading Restrictions: Letter grade

  • Academic Ethics Code

    The code, discussed in the Policy and Procedure Memorandum for Students, March 31, 2002, will be adhered to in this class:

    Students enrolled in the Bloomberg School of Public Health of The Johns Hopkins University assume an obligation to conduct themselves in a manner appropriate to the University's mission as an institution of higher education. A student is obligated to refrain from acts which he or she knows, or under the circumstances has reason to know, impair the academic integrity of the University. Violations of academic integrity include, but are not limited to: cheating; plagiarism; knowingly furnishing false information to any agent of the University for inclusion in the academic record; violation of the rights and welfare of animal or human subjects in research; and misconduct as a member of either School or University committees or recognized groups or organizations.

  • Disability Support Services

    If you are a student with a documented disability who requires an academic accommodation, please contact Betty H. Addison in the Office of Student Life Services:, 410-955-3034, or 2017 E. Monument Street.