180.650.01 | AY 2012-2013 - 2nd Term | 3 Credit(s)
Th 5:30:00 PM
  • Contact Information
    Bruce Trock
  • Course Learning Objectives

    Information not required for this course type

  • Course Description
    Lectures by current practitioners of cancer prevention control in clinical oncology cover the diagnosis, treatment, and prevention/screening measures used for cancers such as lung, breast, prostate, colon/rectal, etc.

    Additional Faculty Notes:

    Class Format:  There will be 2 different lecturers every night - each will give a didactic lecture for about 50 minutes, then the last 15-20 minutes of each lecture will be a journal club style discussion of a recent journal article that you will receive the week before the lecture.  Usually the article will address some controversy or an important new advance.  All students should read the article and be prepared to discuss it.  Each student will have to lead the discussion of one of the articles during the semester.  You should be prepared to summarize (1) the main point/controversy/scientific advance that the paper addressed, (2) why it was a controversy or important (3) what they did (methodologically) that was an improvement over studies to date, (4) the important results they found or side of the controversy they supported - if there are relevant figures or tables with the results, point the class to them and briefly summarize them (5) YOUR assessment of how well they've solved the problem, or which side of the controversy you think is best supported (and where there are still gaps).  This sounds like a lot but really isn't - you don't have to memorize it.  Just know what they did, why they did it, how they did it, and what they found.  A good approach for your presentation (for data-driven papers) is to summarize the background and the objective, then go to relevant data shown in tables and figures and discuss it. When you are leading the discussion of an article you should really try to get your classmates involved in discussion. You should NOT prepare slides.


    Midterm and Final Exam:  This year we have 1 less class period than usual so the date and format of the Midterm hasn’t been decided yet (but WON’T be something you have to study for over Thanksgiving break).  The Final Exam will be on December 20.  The Final will primarily cover material presented since the mid-term, but may include major concepts from the first half of the course.  Both tests will cover all of the lectures – what is said by the lecturers as well as what is on the slides, and major issues from the journal articles.  The exams will both be multiple choice and short answer and are not hard if you pay attention during the lectures.  Even though you will get copies of the slides you'll be responsible for anything the lecturer says that is not on the slides themselves so take good notes.


    Course Materials – they will be posted on Courseplus and you will receive instructions for accessing them.  After you get instructions, if you have trouble getting access, let me know.  Each week the articles for the next week will be posted, and lecture powerpoint slides will be posted before the lecture or handed out in class.

  • Intended Audience

    Additional Faculty Notes:

    Students with an interest in cancer who are likely to engage in cancer research but not be involved in care of patients with cancer.

  • Methods of Assessment
    Student evaluation based on two exams.

    Additional Faculty Notes:

    Grade based on midterm and final exam, presentation of a journal article, and class participation.

  • Prerequisites
    Basic epidemiology and toxicology useful, but not required
  • Required Text(s)

    Additional Faculty Notes:

    None.  Required readings will be from journal articles that will be handed out or posted on CoursePlus

  • Course Schedule

    Please see the course Session for a full list of dates and items for this course.

  • Academic Ethics Code

    Students enrolled in the Bloomberg School of Public Health of The Johns Hopkins University assume an obligation to conduct themselves in a manner appropriate to the University's mission as an institution of higher education. A student is obligated to refrain from acts which he or she knows, or under the circumstances has reason to know, impair the academic integrity of the University. Violations of academic integrity include, but are not limited to: cheating; plagiarism; knowingly furnishing false information to any agent of the University for inclusion in the academic record; violation of the rights and welfare of animal or human subjects in research; and misconduct as a member of either School or University committees or recognized groups or organizations.

  • Welcome Message



  • Course topics

    Thursday, November 1, 2012


    1.         Introduction to the cancer problem (Trock)

    A.        How do we evaluate if progress is being made against cancer?

    B.         Trends in cancer incidence and mortality over time

    C.         Factors influencing trends and their interpretation



    Thursday, November 8, 2012


    2.         Stomach and Esophageal Cancer (Duncan)    

                A.        Epidemiology of esophageal cancer

                B.         Presentation and work-up

                C.         Management/Treatment


    3.         Colorectal Carcinoma (Duncan)

                A.        Etiology and diagnosis of colorectal cancer

                B.         Screening and prevention

                C.         Surgical treatment of primary tumor

                D.        Surgical treatment of metastases



    Thursday, November 15, 2012


    4.         Hepatocellular Carcinoma (Pawlik)

                A.        Etiology and diagnosis of hepatocellular carcinoma.

                B.         Screening methods for this disease

                C.         Chemotherapy options: emerging data

                D.        Transplantation versus resection for hepatocellular carcinoma

                E.         Locoregional therapy for hepatocellular carcinoma


    5.         Lung Cancer (Brock)

                A.        Causes of lung cancer and the scope of the problem.

                B.         Clinical presentation and diagnosis of lung cancer.

                C.         Management and treatment of the disease.

                D.        Clinical trials for treatment and prevention 



    Thursday, November 22, 2012:         Thanksgiving Break



    Thursday, November 29, 2012:                       


    6.         Pancreatic Cancer:  From genes to patients (Wolfgang)

    1. Pancreatic cancer as a major cause of cancer death
    2. The genetic basis of pancreatic cancer.
    3. Application of genetics to early detection, classification, familial pancreatic cancer, and treatment.


    7.         Prostate Cancer (Han)

                A.        Natural history, ethnic differences in disease, diagnosis and risk factors

                B.         What is the PSA test and how it is used?

                C.         Treatment of prostate cancer (surgical and medical oncology strategies).

                D.        Societal impact, psychosocial factors



    Thursday, December 6, 2012


    8.         Melanoma (Lange)

                A.        Risk factors for melanoma

                B.         Diagnosis and staging

                C.         Surgical treatment of melanoma

                D.        Screening for melanoma


    9.         Breast Cancer (Armstrong)

                A.        Risk factors for breast cancer

                B.         Diagnosis and staging (including in situ)

                C.         Surgical treatment of breast cancer

                D.        Adjuvant and metastatic treatment of breast cancer

                E.         Screening for breast cancer



    Thursday, December 13, 2012


    10.       Head and Neck Cancer (Ha)

                A.        Etiology and diagnosis of head and neck cancer.

                B.         Treatment and managment of head and neck cancer.

                C.         Future directions in treatment and research for head and neck cancer


    11.       Chemoprevention of Cancer (Taylor)

                A.        Background for cancer prevention and chemoprevention

                B.         Drug interventions

                C.         Nutritional interventions

                                        -  1st generation trials

                                        -  2nd generation trials

                D.        Summary and future directions



    Thursday, December 20, 2012


    Final Exam

  • Course Objectives(from old syllabus)

    1.         To gain an understanding of the multiple manifestations of tumors as different organ sites and the implications of a given diagnosis for treatment.

    2.         To gain an understanding of the state-or-the-art in early detection and screening of the major cancers affecting people living in this region.

    3.         To gain an understanding of issues that influence access and quality of care.

    4.         To gain an understanding of the needs and care of the dying patient.

    5.         To gain an understanding of the role clinical trials play in cancer therapy.

    6.         To become familiar with current controversies in cancer care.

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