Course Learning ObjectivesAfter successfully completing this course, you will be able to do the following: • Define the main features of viral, prokaryotic, and eukaryotic genomes • Define the relevance of various genomes to human disease • Use web-based tools for genome analysis (e.g. annotation and comparison) • Read papers on the sequencing of the human genomes and other genomes, and evaluate the quality and limitations of the analytic approaches
Explores genomes across the tree of life, using the tools of bioinformatics. Topics include viruses; bacteria and archaea; protozoa (e.g. Plasmodium); plants (with a focus on Arabidopsis and rice); the fungi; the metazoans (Drosophila, C. elegans, the rodents, the primates, and human). Each lecture highlights features of the relevant genome(s), key websites and bioinformatics tools, the phylogenetic context in which to understand the significance of the organism, and genomics-based approaches to human disease. Weekly computer labs introduce students to genomics software available on the internet, including tools for genome annotation, comparison, and analysis.
Graduate students in the School of Public Health and School of Medicine.
Methods of Assessment
Grading Policy: One midterm exam; one final exam; weekly quizzes.
Grading Restrictions: Letter grade
Academic Ethics Code
The code, discussed in the Policy and Procedure Memorandum for Students, March 31, 2002, will be adhered to in this class:
Students enrolled in the Bloomberg School of Public Health of The Johns Hopkins University assume an obligation to conduct themselves in a manner appropriate to the University's mission as an institution of higher education. A student is obligated to refrain from acts which he or she knows, or under the circumstances has reason to know, impair the academic integrity of the University. Violations of academic integrity include, but are not limited to: cheating; plagiarism; knowingly furnishing false information to any agent of the University for inclusion in the academic record; violation of the rights and welfare of animal or human subjects in research; and misconduct as a member of either School or University committees or recognized groups or organizations.
Disability Support Services
If you are a student with a documented disability who requires an academic accommodation, please contact Betty H. Addison in the Office of Student Life Services: email@example.com, 410-955-3034, or 2017 E. Monument Street.