180.640.01 | AY 2012-2013 - 3rd Term | 4 Credit(s)
TTh 2:30:00 PM
  • Contact Information
    Paul Strickland
  • Course Learning Objectives

    Information not required for this course type

  • Course Description
    Emphasizes the scientific basis of molecular epidemiology and provides examples of the application of molecular biology, analytical chemistry, and toxicology to the study of chronic disease etiology and its public health application, including examples in human cancer, cardiovascular, immunological, and neurological diseases. Also discusses methodological and study design problems.
  • Methods of Assessment
    Student evaluation based on a paper (50%) and a final exam (50%).
  • Prerequisites
    340.601-602 or consent of instructor
  • Required Text(s)

    Additional Faculty Notes:

    Suggested References:

    Molecular Epidemiology of Chronic Diseases, C Wild, P Vineis & S Garte: Wiley (2008).

    Molecular Epidemiology, PA Schulte & FP Perera: Academic Press (1993).

    Application of Biomarkers in Cancer Epidemiology. P Toniolo et al Eds, IARC Sci Publ No. 142, IARC Press (1997).

    Metabolic Polymorphisms and Susceptibility to Cancer. P Vineis et al Eds, IARC Sci Publ No. 148, IARC Press (1999).

  • Course Schedule

    Please see the course Session for a full list of dates and items for this course.

  • Academic Ethics Code

    Students enrolled in the Bloomberg School of Public Health of The Johns Hopkins University assume an obligation to conduct themselves in a manner appropriate to the University's mission as an institution of higher education. A student is obligated to refrain from acts which he or she knows, or under the circumstances has reason to know, impair the academic integrity of the University. Violations of academic integrity include, but are not limited to: cheating; plagiarism; knowingly furnishing false information to any agent of the University for inclusion in the academic record; violation of the rights and welfare of animal or human subjects in research; and misconduct as a member of either School or University committees or recognized groups or organizations.

  • Course topics

    Overview: Molecular Biomarkers (Strickland); Biomarkers of Carcinogen Exposure:PAHs (Strickland); Epidemiological Issues: Methods, Design & Examples (Rothman & Lan); Genetic Susceptibility to Cancer (Strickland); Molecular Epidemiology of Cardiovascular Disease (Coresh); Metabolic Susceptibility Factors and Cancer Risk (Strickland); Metal Exposure and Cardiovascular Disease (Navas-Acien); Biomarkers of Biological Agents and Inflammation in Cancer (Strickland); Molecular Epidemiology of Lead Exposure (Schwartz); Molecular Epidemiology of Lead Susceptibility & Effect (Schwartz); Biomarkers of Infectious Diseases and AIDS Progression (Strickland);  Review of Group Study Proposals (Strickland/Rothman); DNA Processing/Repair as a Susceptibility Factor for Cancer (Strickland); Ethical Issues (Strickland) 

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