Course Learning Objectives1. Define the genetic systems that encode molecules with integral roles in immune regulation. 2. Assess the impact of allelic polymorphism in certain genes on features such as gene expression and MHC restriction. 3. Define the basic mechanisms for expansion of the immunologic repertoire of antigen receptors. 4. Understand the implications of population differences in the frequencies of genes involved in immune responses.
Presents the genetic basis of immune responsiveness. Reviews the genetic mechanisms responsible for generation of diversity in the genes for immunoglobulins, the T cell receptor molecules, the major histocompatibility molecules, and other key molecules of the immuno-globulin superfamily. Discusses mechanisms and statistical evaluation of immunogenetic associations with susceptibility or resistance to disease.
Methods of Assessment
Grading Policy: Student evaluation based on a mid-term exam, and a final exam, or paper and oral presentation.
Grading Restrictions: Letter grade
260.611-612 or introductory course in immunology; introductory course in genetics
Academic Ethics Code
The code, discussed in the Policy and Procedure Memorandum for Students, March 31, 2002, will be adhered to in this class:
Students enrolled in the Bloomberg School of Public Health of The Johns Hopkins University assume an obligation to conduct themselves in a manner appropriate to the University's mission as an institution of higher education. A student is obligated to refrain from acts which he or she knows, or under the circumstances has reason to know, impair the academic integrity of the University. Violations of academic integrity include, but are not limited to: cheating; plagiarism; knowingly furnishing false information to any agent of the University for inclusion in the academic record; violation of the rights and welfare of animal or human subjects in research; and misconduct as a member of either School or University committees or recognized groups or organizations.
Disability Support Services
If you are a student with a documented disability who requires an academic accommodation, please contact Betty H. Addison in the Office of Student Life Services: firstname.lastname@example.org, 410-955-3034, or 2017 E. Monument Street.