GENOMICS FOR PUBLIC HEALTH Syllabus

120.608.01 | AY 2012-2013 - 4th Term | 3 Credit(s)
TTh 1:30:00 PM
  • Contact Information
    Faculty
    Roger McMacken
    P.C. Huang
    Terry Brown
    Randy Bryant
    Daniela Drummond-Barbosa
  • Course Learning Objectives

    Upon successfully completing this course, students will be able to:

    • Describe the organization of the human genome and the genomes of selected model organisms
    • Explain how human disease genes are mapped
    • Analyze DNA, RNA, or protein sequences through the use of public domain databases and algorithms
    • Explain how DNA microarrays, protein microarrays, and rapid whole-genome-sequencing technologies can be used to analyze or treat human disease in individuals and populations
    • Describe basic recombinant DNA, proteomic, and biotechnological methodologies used in the analysis of human disease
    • Explain how modifications to chromatin or the presence of gut microbial flora impact expression of selected human genes.
  • Course Description

    Introduces genomics and modern genetic technologies, emphasizing their application to significant public health problems, to students who have limited prior coursework in molecular biology or molecular genetics. Integrates lectures and discussions with computer exercises in laboratory sessions. Topics include fundamental principles of molecular biology; genome sequencing and structure; gene cloning; mapping of human disease genes; use of DNA microarrays, protein microarrays, and next generation rapid DNA sequencing methodologies in analysis and treatment of human disease; comparative genomics of model and pathogenic organisms; and genetically modified organisms.

    Additional Faculty Notes:

    Introduces genomics and modern genetic technologies, with emphasis on their application to significant public health problems to students who have an understanding of the fundamentals of molecular biology. Lectures and discussions are integrated with computer exercises in laboratory sessions. Topics include human genomics; modern technologies used in genomic analysis; genome sequencing and structure; gene cloning; nucleic acid hybridization and PCR; mapping of human disease genes; use of DNA microarrays, protein microarrays, and individual genome sequences in analysis and treatment of human disease; comparative genomics of model and pathogenic organisms;  and genetically modified organisms.

  • Intended Audience
    MPH students, students in the genetic epidemiology program, and all graduate students interested in learning about the application of genomics and modern genetic technologies to human disease and to specific public health concerns. This is an introductory course and is not intended for advanced PhD students in the laboratory sciences.

    Additional Faculty Notes:

    MHS students in the laboratory sciences, students in the genetic epidemiology program, and all MPH and doctoral graduate students interested in learning about the application of genomics and modern genetic technologies to specific public health problems. This is an introductory course and is not specifically designed for advanced PhD students in the laboratory sciences.

  • Methods of Assessment
    Student evaluation based on four online quizzes (1/4 of total), two computer lab exercises (1/4 of total) and a final exam (1/2 of total).

    Additional Faculty Notes:

    The course grade is dependent on student performance in online quizzes (25 %), on a computer laboratory exercise (25 %) and on a final exam (50 %).

  • Prerequisites

    A college level course in biology or a related subject.

    Additional Faculty Notes:

    Registered students should have an understanding of the basic tenets of molecular biology.

  • Required Text(s)

    Additional Faculty Notes:

    No specific textbook is required.  Refer to the course syllabus for suggested sources of information.

  • Course Schedule

    Please see the course Session for a full list of dates and items for this course.

  • Academic Ethics Code

    Students enrolled in the Bloomberg School of Public Health of The Johns Hopkins University assume an obligation to conduct themselves in a manner appropriate to the University's mission as an institution of higher education. A student is obligated to refrain from acts which he or she knows, or under the circumstances has reason to know, impair the academic integrity of the University. Violations of academic integrity include, but are not limited to: cheating; plagiarism; knowingly furnishing false information to any agent of the University for inclusion in the academic record; violation of the rights and welfare of animal or human subjects in research; and misconduct as a member of either School or University committees or recognized groups or organizations.

  • Disability Support Services
    If you are a student with a documented disability who requires an academic accommodation, please contact the Office of Student Life Services at 410-955-3034 or via email at dss@jhsph.edu.