PROTEIN BIOINFORMATICS AND STRUCTURE Syllabus
Course Learning Objectives1. Define protein physical properties and analyze protein structure. 2. Explain how proteins are studied experimentally and how data is generated in high- throughput experiments. 3. Describe the computational methods used to study protein structure and interactions. 4. Master the use of protein databases and protein modeling and visualization software
Provides students with an overview of protein bioinformatics including computational and experimental approaches. Introduces amino acid and protein physical properties as well as the alignment and evolution of protein sequences. Presents protein structure and methods of structure determination as well as the use of protein databases and software for visualizing proteins and generating publication quality figures. Discusses methods for secondary and tertiary protein structure prediction including homology modeling. Also covers methods for modeling small/molecule-protein interactions within the context of rational drug discovery and design. Finally, introduces students to experimental and computational aspects of mapping protein interaction networks.
Students interested in learning how to manipulate protein sequence and structural databases, and learning how to find, compare, visualize, model and determine protein structures
Methods of Assessment
Grading Policy: 4 homework assignments and final exam
Grading Restrictions: Letter grade
Introduction to Molecular Biology (120.602) or consent of instructor
Academic Ethics Code
The code, discussed in the Policy and Procedure Memorandum for Students, March 31, 2002, will be adhered to in this class:
Students enrolled in the Bloomberg School of Public Health of The Johns Hopkins University assume an obligation to conduct themselves in a manner appropriate to the University's mission as an institution of higher education. A student is obligated to refrain from acts which he or she knows, or under the circumstances has reason to know, impair the academic integrity of the University. Violations of academic integrity include, but are not limited to: cheating; plagiarism; knowingly furnishing false information to any agent of the University for inclusion in the academic record; violation of the rights and welfare of animal or human subjects in research; and misconduct as a member of either School or University committees or recognized groups or organizations.
Disability Support Services
If you are a student with a documented disability who requires an academic accommodation, please contact Betty H. Addison in the Office of Student Life Services: firstname.lastname@example.org, 410-955-3034, or 2017 E. Monument Street.