260.711.01 | AY 2012-2013 - 4th Term | 3 Credit(s)
TTh 9:00:00 AM
  • Contact Information
  • Course Learning Objectives
    Upon successfully completing this course, students will be able to: 1. Explain how the immune system and cellular brain components contribute to neurological disease. 2. Describe the types and effector functions of resident and peripheral immune cells in the human brain, in health and disease.
  • Course Description

    Covers the origin of specific cells of the central nervous system, immune functions of CNS cells, and trafficking of leukocytes into the CNS with mention of relevant anatomy (blood, brain, barrier, etc). Discusses monocytes, T cells, B cells, cytokines, chemokines, metalloproteinases, and prostaglandins. Explores how these mediators contribute to development, plasticity and pathology of the CNS. Presentations address multiple sclerosis, Creutzfeld and Jacob disease, HIV dementia and Alzheimer’s disease.

  • Intended Audience

    Graduate students, post-graduate students in the medical field, public health, neurosciences, immunology, geriatrics and psychiatry. Other interested students/physicians are also invited.

  • Methods of Assessment

    Grading Policy: Course participation and a final exam.

    Grading Restrictions: Letter grade

  • Prerequisites

    Basic knowledge of brain anatomy, physiology and biology.

  • Academic Ethics Code

    The code, discussed in the Policy and Procedure Memorandum for Students, March 31, 2002, will be adhered to in this class:

    Students enrolled in the Bloomberg School of Public Health of The Johns Hopkins University assume an obligation to conduct themselves in a manner appropriate to the University's mission as an institution of higher education. A student is obligated to refrain from acts which he or she knows, or under the circumstances has reason to know, impair the academic integrity of the University. Violations of academic integrity include, but are not limited to: cheating; plagiarism; knowingly furnishing false information to any agent of the University for inclusion in the academic record; violation of the rights and welfare of animal or human subjects in research; and misconduct as a member of either School or University committees or recognized groups or organizations.

  • Disability Support Services

    If you are a student with a documented disability who requires an academic accommodation, please contact Betty H. Addison in the Office of Student Life Services:, 410-955-3034, or 2017 E. Monument Street.