340.731.01 | AY 2013-2014 - 1st Term | 4 Credit(s)
TTh 9:00:00 AM
  • Contact Information
    Priya Duggal
  • Course Learning Objectives

    Upon successfully completing this course, students will be able to:

    • Present fundamental concepts and methods in genetic epidemiology
    • review basic terminology in genetics and introduce various genetic epidemiology study designs, covering basic analysis, inferences, plus their strengths and limitations
    • Discuss basic terminology in the field of human genetics
    • Discuss the basic principles behind major molecular biology techniques, such as PCR, and their applications in genetic epidemiology studies
    • Discuss various exposures, or markers, used in genetic epidemiology studies
    • Discuss principles of Hardy-Weinberg Equilibrium and be able to estimate allele and genotype frequencies
    • Discuss and calculate simple statistics, such as odds ratios and LOD scores
    • Discuss the difference between linkage and association studies
    • Discuss the difference between family-based and population-based studies
    • Discuss the difference between direct and indirect association studies
    • interpret results of a linkage study
    • interpret results of an association study
    • select an appropriate study design for addressing a particular question
    • Discuss the inferences drawn from the different genetic epidemiology studies
  • Intended Audience
    All students interested in clinical, biological, or genetic public health research.
  • Methods of Assessment
    Student evaluation based on homework, labs, and exams.
  • Prerequisites
    College-level biology
  • Course Schedule

    Please see the course Session for a full list of dates and items for this course.

  • Academic Ethics Code

    Students enrolled in the Bloomberg School of Public Health of The Johns Hopkins University assume an obligation to conduct themselves in a manner appropriate to the University's mission as an institution of higher education. A student is obligated to refrain from acts which he or she knows, or under the circumstances has reason to know, impair the academic integrity of the University. Violations of academic integrity include, but are not limited to: cheating; plagiarism; knowingly furnishing false information to any agent of the University for inclusion in the academic record; violation of the rights and welfare of animal or human subjects in research; and misconduct as a member of either School or University committees or recognized groups or organizations.

  • Course Description
    Presents fundamental concepts and methods in genetic epidemiology. Reviews terminology of genetics, introduces principles of population genetics, and provides an overview of various genetic epidemiology study designs, covering fundamental analyses, inferences, plus their strengths and limitations. Presents methods for assessing familial aggregation/correlation and genetic linkage and association analyses will be presented with an emphasis on how these are used in genetic epidemiology. Covers statistical techniques for modeling inheritance of complex phenotypes in family data. Explains various study designs commonly used in genetic epidemiology to identify the genetic basis of Mendelian as well as common, complex diseases. Discusses the role of high throughput genomics technologies within the context of genetic epidemiology studies.
  • Contact Information(from old syllabus)

    Shan Andrews

    Fei Chen

  • Disability Support Services
    If you are a student with a documented disability who requires an academic accommodation, please contact the Office of Student Life Services at 410-955-3034 or via email at