222.651.01 | AY 2013-2014 - 2nd Term | 3 Credit(s)
MW 1:30:00 PM
  • Contact Information
    Luigi De Luca
  • Course Learning Objectives

    Upon successfully completing this course, students will be able to:

    • apply basic concepts of whole body nutrient homeostasis to nutrient control at the cellular level
    • critically evaluate new findings on the role of nutrients in functions such as cellular differentiation, bone remodeling and cognitive function
    • gain a greater understanding of metabolic pathway interrelationships
  • Course Description
    Provides an in-depth review of the metabolism of major nutrients and its importance in disease states, such as teratogenesis, cardiovascular disease, ageing, cancer, obesity, and liver fibrosis. Focuses on regulatory mechanisms, integration of metabolic pathways, and biochemical and physiological aspects of nutrient metabolism at the whole body, tissue and cellular level. Includes both discussion and lectures.

    Additional Faculty Notes:

    Course Format: Most classes are given by the instructor, but guest lectures are also included. Students will be expected to actively participate in lectures by asking questions and making comments as well as contributing presentations.

  • Intended Audience

    Additional Faculty Notes:
    The course is intended for those with previous coursework in human nutrition and biochemistry.

  • Methods of Assessment

    Additional Faculty Notes:
    Grading is based on class attendance, participation, mid term and a final written examination. Final Exam (40%), Mid term exam (30%), Class participation (15%), Attendance (15%). Students are expected to engage and actively participate in class lectures and discussions. Students are expected to be present for every class period.

  • Prerequisites
    Previous course work in biochemistry and/or the course on Nutritional Biochemistry
  • Required Text(s)

    Additional Faculty Notes:
    Recommended Textbooks 1. Stipanuk MH (ed). Biochemical and Physiological Aspects of Human Nutrition. Saunder, Philadelphia, 2000. ISBN 0-7216-4452-X. 2. Bruce Alberts et al. Molecular Biology of the Cell. 2nd edition. 3. Groff, JL and Gropper, SS (ed.) Advanced Nutrition and Human Metabolism. Third Edition. Wadsworth, 2000.

  • Course Schedule

    Please see the course Session for a full list of dates and items for this course.

  • Academic Ethics Code

    Students enrolled in the Bloomberg School of Public Health of The Johns Hopkins University assume an obligation to conduct themselves in a manner appropriate to the University's mission as an institution of higher education. A student is obligated to refrain from acts which he or she knows, or under the circumstances has reason to know, impair the academic integrity of the University. Violations of academic integrity include, but are not limited to: cheating; plagiarism; knowingly furnishing false information to any agent of the University for inclusion in the academic record; violation of the rights and welfare of animal or human subjects in research; and misconduct as a member of either School or University committees or recognized groups or organizations.

  • Course topics

    Lectures will focus on - Essential nutrients and their key metabolites in gene transciption; How the superfamily of  steroid hormone/retinoid/deltanoid nuclear receptors controls embryogenesis and teratogenesis; Cholesterol metabolism and cardiovascular disease; Obesity and Fatty acid synthesis and oxidation; Carcinogenesis and its modulation by nutrients/phytochemicals, Liver fibrosis and its modulation by nutrients; How nutrition may affect the ageing process?

  • Contact Information(from old syllabus)

    Diane Reese
    Office: JHSPH, Center for Human Nutrition, E2543
    Tel: 410-955-2787

    Luigi De Luca, Ph.D.
    Office: JHSPH, Center for Human Nutrition, E2539

  • Course Objectives(from old syllabus)

    Upon completing this course, students will be able to: a) Understand the role of specific essential nutrients in physiology and whole body health and homeostasis; b) Gain an in depth appreciation of mechanisms of action of essential nutrients, including vitamins and minerals; c) Critically evaluate new findings on the role of nutrients in various functions; d) Comprehend and dissect metabolic pathways.

  • Disability Support Services
    If you are a student with a documented disability who requires an academic accommodation, please contact the Office of Student Life Services at 410-955-3034 or via email at