340.732.01 | AY 2013-2014 - 2nd Term | 3 Credit(s)
TTh 9:00:00 AM
  • Contact Information
    Terri H. Beaty
  • Course Learning Objectives

    After completing this course, you should be able to:

    • Demonstrate the concepts of linkage disequilibrium and haplotypes
    • Calculate LD coefficients and haplotype frequencies
    • Explain the utility of the HapMap project and the 1000Genomes project
    • Use public databases to select tagSNPs or estimate LD coverage
    • Describe the various design strategies for genetic studies and discuss the advantages and disadvantages of each
    • Explain the difference between genetic association and genetic linkage
    • Perform genetic association tests in family-based and unrelated samples
    • Discuss the concept of confounding by ancestry in genetic analyses
    • Apply tools to adjust for confounding by ancestry
    • Perform estimation and tests of gene-by-gene and gene-by-environment interactions
    • Apply the above concepts in the context of genome-wide association studies
    • Perform and interpret linkage analyses on family data
  • Course Description
    Second offering in a four-quarter series. Details the concepts of linkage disequilibrium, haplotypes, and the use of public information to inform study design and analysis related to haplotypes. Presents genetic association analyses of quantitative and qualitative disease-related phenotypes for both unrelated and family-based sampling designs. Reviews the concepts and tools related to confounding by ancestry, approaches for genome-wide association studies and for assessment of gene-by-gene and gene-by-environment interactions; and methods for genetic linkage analysis. Select class sessions are dedicated to discussion-based and computer-based labs to further illustrate the methods taught.
  • Intended Audience
    Doctoral and Masters students in Epidemiology & Biostatistics.
  • Methods of Assessment

    Student evaluation based on take home lab, paper critique, group presentation, and a final exam.

  • Prerequisites
    introduction to genetics course
  • Course Schedule

    Please see the course Session for a full list of dates and items for this course.

  • Academic Ethics Code

    Students enrolled in the Bloomberg School of Public Health of The Johns Hopkins University assume an obligation to conduct themselves in a manner appropriate to the University's mission as an institution of higher education. A student is obligated to refrain from acts which he or she knows, or under the circumstances has reason to know, impair the academic integrity of the University. Violations of academic integrity include, but are not limited to: cheating; plagiarism; knowingly furnishing false information to any agent of the University for inclusion in the academic record; violation of the rights and welfare of animal or human subjects in research; and misconduct as a member of either School or University committees or recognized groups or organizations.

  • Teaching Assistant

    Shan Andrews (

    Office hours: Wednesday, 3-4pm W4007

  • Disability Support Services
    If you are a student with a documented disability who requires an academic accommodation, please contact the Office of Student Life Services at 410-955-3034 or via email at