PRINCIPLES OF GENETIC EPIDEMIOLOGY 2 Syllabus
Course Learning Objectives
After completing this course, you should be able to:
- Demonstrate the concepts of linkage disequilibrium and haplotypes
- Calculate LD coefficients and haplotype frequencies
- Explain the utility of the HapMap project and the 1000Genomes project
- Use public databases to select tagSNPs or estimate LD coverage
- Describe the various design strategies for genetic studies and discuss the advantages and disadvantages of each
- Explain the difference between genetic association and genetic linkage
- Perform genetic association tests in family-based and unrelated samples
- Discuss the concept of confounding by ancestry in genetic analyses
- Apply tools to adjust for confounding by ancestry
- Perform estimation and tests of gene-by-gene and gene-by-environment interactions
- Apply the above concepts in the context of genome-wide association studies
- Perform and interpret linkage analyses on family data
Course DescriptionSecond offering in a four-quarter series. Details the concepts of linkage disequilibrium, haplotypes, and the use of public information to inform study design and analysis related to haplotypes. Presents genetic association analyses of quantitative and qualitative disease-related phenotypes for both unrelated and family-based sampling designs. Reviews the concepts and tools related to confounding by ancestry, approaches for genome-wide association studies and for assessment of gene-by-gene and gene-by-environment interactions; and methods for genetic linkage analysis. Select class sessions are dedicated to discussion-based and computer-based labs to further illustrate the methods taught.
Intended AudienceDoctoral and Masters students in Epidemiology & Biostatistics.
Methods of Assessment
Student evaluation based on take home lab, paper critique, group presentation, and a final exam.
Prerequisitesintroduction to genetics course
Please see the course Session for a full list of dates and items for this course.
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