187.632.01 | AY 2013-2014 - 2nd Term | 4 Credit(s)
MWF 10:30:00 AM
  • Contact Information
    Shyam S. Biswal
    Valeria Culotta
  • Course Learning Objectives

    Upon successfully completing this course, students will be able to:

    • Analyze and Discuss the literature regarding a wide array of topics relevant to molecular toxicology, including the molecular response to environmental stress and pathways of carcinogenesis and DNA repair
    • Describe various gene-environment interactions that lead to either cell adaptation, cell death or disease in response to toxins in the environment
    • Discuss the application of various state-of-the-art techniques for molecular analyses, including proteomics, genomics, bioremediation, surface plasma resonance, transgenic animals for research and polymorphism monitoring
  • Course Description
    Reviews the mechanisms of environmental diseases at the molecular and genetic levels through faculty lectures and discussion of scientific papers. Presents most recent technological advances in the molecular and genetic tools available to study environmental diseases, which includes omics technologies (proteomics, genomics and metabolomics), microarray, nextgen sequencing for genetic variations (SNPs), bioinformatics, transgenic animals and emerging alternative animal models. Topics include mechanisms and cell signaling pathways involved in oxidative, nitrosative stress and inflammation in response to exposure to air pollutants, metals and other environmental toxicants that causes non-communicable diseases such as cancer, lung and heart diseases. Addresses the impact of environmental toxicants on cell growth, cell death, DNA repair, epigenetics, inflammation and the multi-stages of carcinogenesis which cause major non-communicable diseases and impact public health.
  • Intended Audience
    students interested in toxicology at the molecular and genetic levels
  • Methods of Assessment
    Total grade will be based on midterm and final exams and attendance.
  • Prerequisites
    187.610 and a basic course in molecular biology or consent of instructor.
  • Course Schedule

    Please see the course Session for a full list of dates and items for this course.

  • Academic Ethics Code

    Students enrolled in the Bloomberg School of Public Health of The Johns Hopkins University assume an obligation to conduct themselves in a manner appropriate to the University's mission as an institution of higher education. A student is obligated to refrain from acts which he or she knows, or under the circumstances has reason to know, impair the academic integrity of the University. Violations of academic integrity include, but are not limited to: cheating; plagiarism; knowingly furnishing false information to any agent of the University for inclusion in the academic record; violation of the rights and welfare of animal or human subjects in research; and misconduct as a member of either School or University committees or recognized groups or organizations.

  • Disability Support Services
    If you are a student with a documented disability who requires an academic accommodation, please contact the Office of Student Life Services at 410-955-3034 or via email at dss@jhsph.edu.