STEM CELLS AND THE BIOLOGY OF AGING AND DISEASE Syllabus
This course is intended to expose students to cutting-edge topics in stem cell biology through lectures based on primary literature covering major classic and current advances. Topics include basic stem cell biology in a variety of invertebrate and vertebrate systems including germline, neural, hematopoietic, and epithelial stem cells; the impact of whole-body physiology, including diet, cancer and other disease states, wound healing, and aging on stem cells; embryonic stem cells and pluripotency; therapeutic applications of stem cells and their ethical implications.
Course Learning Objectives
Upon successfully completing this course, students will be able to:
- explain some of the basic cellular and molecular mechanisms that ensure self-renewal of stem cells.
- compare and contrast the regulation and function of stem cells in different systems
- explain how diet, disease and aging impact stem cell behavior and function
- understand the molecular basis of embryonic stem cell pluripotency
- describe potential stem cell based therapies
- discuss the ethical and policy issues in stem cell research and its therapeutic applications.
Intended AudienceMaster's students, PhD students, Postdoctoral Fellows
A course in biochemistry or molecular biology or cell biology (undergrad or graduate)
Methods of Assessment
Attendance and participation are required. Evaluation will be based on midterm (40% of grade) and final (60% of grade) exams.
Students will be expected to read one or two recent reviews and/or primary literature papers assigned prior to each class by each lecturer. All papers will be provided on the CoursePlus website, and should be read by students prior to class.
Please see the course Session for a full list of dates and items for this course.
Academic Ethics Code
The code, discussed in the Policy and Procedure Memorandum for Students, March 31, 2002, will be adhered to in this class:
Students enrolled in the Bloomberg School of Public Health of The Johns Hopkins University assume an obligation to conduct themselves in a manner appropriate to the University's mission as an institution of higher education. A student is obligated to refrain from acts which he or she knows, or under the circumstances has reason to know, impair the academic integrity of the University. Violations of academic integrity include, but are not limited to: cheating; plagiarism; knowingly furnishing false information to any agent of the University for inclusion in the academic record; violation of the rights and welfare of animal or human subjects in research; and misconduct as a member of either School or University committees or recognized groups or organizations.
90-100: Outstanding - A
80-89: Commendable - B
70-79: Acceptable - C
Disability Support ServicesIf you are a student with a documented disability who requires an academic accommodation, please contact Betty H. Addison in the Office of Student Life Services: firstname.lastname@example.org, 410-955-3034, or 2017 E. Monument Street.