260.712.01 | AY 2013-2014 - 4th Term | 3 Credit(s)
M 6:00:00 PM
  • Contact Information
    Daniela Cihakova
  • Course Learning Objectives

    Upon successfully completing this course, students will be able to:

    • understand current topics, problems, and approaches in the modern application of immunologic principles in the clinic. The emphasis is on understanding the fundamental mechanisms underlying immunologic diseases. The goal is not to teach clinical presentation and diagnostic procedures.
  • Course Description

    Originally understood to be the central defense against infectious disease, it has since become clear that the immune system participates in a broad variety of disease states, and the maintenance of health independent of infection. This course will survey these mechanisms, focusing on translations of our understanding of basic immunology into utility in the modern clinic. In particular, unifying themes and mechanisms shared by these various settings of health and disease will be emphasized.




  • Intended Audience
    Graduate Students (MSc & PhD candidates) in health science fields, Med. students, Physicians and other health care professionals.
  • Methods of Assessment

    Student evaluation based on small in-class quizzes, attendance, participation and presentation.

  • Prerequisites
    a course in Basic Immunology or an equivalent
  • Required Text(s)

    Required materials (Powerpoint presentations, notes, papers) will be available on CoursePlus.

  • Recommended Text/Materials

    Clinical Immunology, Rich, et al. 4th ed.

    Janeway’s Immunobiology, Murphy, et al. 8th ed.

    Fundamental Immunology, Paul, et al. 7th ed.

    Pocket guide to Clinical Immunology, Folds JD

  • Course Schedule

    Please see the course Session for a full list of dates and items for this course.


    week 1: Mar 24 – Introduction and overview, review of basic immunology: Jobert Barin, PhD Review fundamental immunologic concepts in a broad overview of the immune system.

    week 2: Mar 31 – autoimmunity, chronic inflammatory disease: Erika Darrah, PhD

    Recognize the multiple immune mechanisms that contribute to autoimmunity; Discuss how these mechanisms apply to human diseases, and how our understanding of them has direct implications on our therapeutic interventions in autoimmune diseases.

    week 3: Apr 7 – immunodeficiency: Daniela Cihakova, MD PhD D(ABMLI)

    Recognize mechanisms and manifestations of primary and secondary immune deficiencies. 

    week 4: Apr 14 – allergy, atopy, asthma: Nicola Heller, PhD Study mechanisms of allergy and all different types of hypersensitivity reactions and their examples in clinical immunology. Midterm Quiz

    week 5: Apr 21 – host-microbiome interactions in the gut Daniel Peterson, MD PhD Learn pathophysiology of infectious diseases, mechanisms of interactions between host and infectious and commensal microorganisms.

    week 6: Apr 28 – Immunodiagnostics: Elizabeth Stafford, PhD: FDA, CDRH; Daniela Cihakova: Overview the pipeline of translating novel diagnostics and therapeutics into the clinic. Discuss unique challenges and opportunities of immunologic diagnostics and therapeutic approaches.

    week 7: May 5 – transplantation: Quan Nhu, MD PhD Discuss the alloimmune response including the origin of alloimmune T lymphocytes and the difference between direct and indirect alloimmune responses

    week 8: May 12 – tumor immunity: Eric Lutz, PhD; Kim Noonan, PhD

    Discuss current understanding of native host defense to neoplasia and tumor. Survey current and future approaches for exploiting tumor immunity as therapeutics. Final Quiz

  • Academic Ethics Code

    Students enrolled in the Bloomberg School of Public Health of The Johns Hopkins University assume an obligation to conduct themselves in a manner appropriate to the University's mission as an institution of higher education. A student is obligated to refrain from acts which he or she knows, or under the circumstances has reason to know, impair the academic integrity of the University. Violations of academic integrity include, but are not limited to: cheating; plagiarism; knowingly furnishing false information to any agent of the University for inclusion in the academic record; violation of the rights and welfare of animal or human subjects in research; and misconduct as a member of either School or University committees or recognized groups or organizations.

  • Grading Policy

    20%: small in-class quizzes

    30%: attendance

    50%: participation and presentation

  • Disability Support Services
    If you are a student with a documented disability who requires an academic accommodation, please contact the Office of Student Life Services at 410-955-3034 or via email at