340.607.01 | AY 2013-2014 - 3rd Term | 4 Credit(s)
MWF 1:30:00 PM
  • Contact Information
    Josef Coresh
  • Course Learning Objectives

    Upon successfully completing this course, students will be able to:

    • discuss the definition and symptoms associated with the various cardiovascular diseases, including coronary artery disease, cerebrovascular disease, and kidney disease
    • describe the major cardiovascular disease risk factors (hypertension, hypercholesterolemia, obesity, diabetes, and smoking) as well as key pathophysiologic processes (atherosclerosis, inflammation and oxidative damage)
    • list the pathogenic sequence of events leading to atherosclerosis and cardiovascular disease is discussed as well as the environmental, behavioral and genetic influences on the underlying processes
    • discuss strategies for primary and secondary prevention as well as relevant cohort studies and clinical trials are reviewed
    • discuss risk score and behavioral aspects of risk as a basis for prevention as a foundation for epidemiologic study design and research
  • Course Description
    Discusses the epidemiology and prevention of cardiovascular disease, focusing on coronary heart disease, stroke, and end stage renal disease, emphasizing the interrelationships of biological and behavioral aspects. Focuses on established major modifiable risk factors for cardiovascular diseases, putative risk factors, and genetic susceptibility. Covers the social burden of disease and prevention strategies.
  • Intended Audience

    Students at all levels interested in understanding cardiovascular epidemiology and its methodologic underpinnings. Required for the cardiovascular epidemiology area of concentration and advanced courses in cardiovascular epidemiology.

  • Methods of Assessment

    Student evaluation based on 3 assignments (70%), and a final exam (30%).

  • Prerequisites
    340.751 or 340.601 or equivalent; 140.622 or equivalent; and knowledge of clinical and pathological aspects of diseases covered
  • Required Text(s)

    Epidemiology and Prevention of Cardiovascular Disease: A Global Challenge

    Author: Darwin R. Labarthe 

    Publisher: Jones & Bartlett Publishers.,

    ISBN-10: 0763746894 | ISBN-13: 978-0763746896 | Publication Date: March 23, 2010 | Edition: 2


  • Course Schedule

    Please see the course Session for a full list of dates and items for this course.

  • Academic Ethics Code

    Students enrolled in the Bloomberg School of Public Health of The Johns Hopkins University assume an obligation to conduct themselves in a manner appropriate to the University's mission as an institution of higher education. A student is obligated to refrain from acts which he or she knows, or under the circumstances has reason to know, impair the academic integrity of the University. Violations of academic integrity include, but are not limited to: cheating; plagiarism; knowingly furnishing false information to any agent of the University for inclusion in the academic record; violation of the rights and welfare of animal or human subjects in research; and misconduct as a member of either School or University committees or recognized groups or organizations.

  • Course topics

    Topics covered in this course are: - Overview and importance of cardiovascular disease - Clinical aspects of cardiovascular disease - Atherosclerosis - Study design: measurement of outcomes and exposures - Imaging atherosclerosis - Blood pressure and risk of CVD - Antihypertensive treatment trials - Lipids and risk of cardiovascular disease: metabolism and observational data - Lipids and risk of cardiovascular disease: clinical trials - Post-menopausal estrogen replacement and cardiovascular disease - Methods of nutrition assessment & CVD - Oxidative modification hypothesis of CVD - Inflammation and cardiovascular disease - Polyunsaturated fatty acid intake and risk of CVD - Psychosocial risk factors - Epidemiology of stroke - Obesity and CVD - Epidemiology of diabetes and its complications - Physical activity and CVD - Genetics and CVD - Genetic epidemiology of diabetes and obesity - Chronic kidney disease as a vascular disease - AHA guidelines  Note: Some lectures times may be divided into 50 minute lecture and a 30 minute informal journal club

  • Contact Information

    Josef Coresh, MD, PhD
    Office: 2024 E. Monument St, Ste 2-600
    Tel: 410-955-0495

    Casey Rebholz, PhD, MPH
    Office: 2024 E. Monument St, Ste 2-600

    Wen Hong (Linda) Kao, Ph.D, M.H.S.
    Office: 615 N. Wolfe St., Room W6513B
    Tel: 410-614-0945

    Michael Blaha, MD, MPH
    600 N. Wolfe St. Carnegie 565A
    Tel: (443)287-7343

    Erin Michos, M.D., M.H.S.
    Office: Carnegie 568, 600 N. Wolfe Street
    Tel: 410-502-6813

    Elizabeth Selvin, MPH, PhD
    Office: 2024 E. Monument St., Ste 2-600

    Jeanne Clark, MD, MPH
    Office: 2024 E. Monument St., Ste 2-600
    Tel: 410-614-1135

    Kunihiro Matsushita, MD, PhD
    Office: 615 N. Wolfe St., Room W6017
    Tel: 443-287-8766

    Lawrence Appel, M.D., M.P.H.
    Office: 2024 E. Monument St., Ste 2-600
    Tel: 410-614-0986

    E. Pete Miller III, M.D., Ph.D.
    Office: 2024 E. Monument St., Suite 1-500
    Tel: 410-502-6444

    Paul K. Whelton, M.D., M.Sc.
    Office: Loyola University Health System
    Tel: 708-216-3215

    Richey Sharrett, Dr.PH, M.D.
    Office: 615 N. Wolfe Street, Rm E6518
    Tel: 443-287-6178

    Kerry J. Stewart, Ed.D.
    Office: Johns Hopkins Bayview, 4940 Eastern Avenue
    Tel: 410-550-0870

    Eliseo Guallar, M.D., Dr.PH
    Office: 2024 E. Monument St., Suite 2-600
    Tel: 410-614-0574

  • Disability Support Services
    If you are a student with a documented disability who requires an academic accommodation, please contact the Office of Student Life Services at 410-955-3034 or via email at