SEMINAR ON AGING, COGNITION AND NEURODEGENERATIVE DISORDERS Syllabus
Course Learning Objectives
Upon successfully completing this course, students will be able to:
- classify the major domains of cognition and describe the age-related changes that occur in each cognitive domain
- to classify the major neurodegenerative disorders related to age and describe the clinical presentation and pattern of cognitive change in each disorder
- to identify gaps in discuss concerning age-related cognitive change and the primary neurodegenerative disorders and apply concepts to the development and evaluation of future interventions for age-related cognitive decline and neurodegenerative disorder
Course DescriptionAddresses age-related cognitive and neuropsychiatric disorders that are of particular importance with the rapid expansion of the aging population. Focuses on the major domains of cognition and comparison of the age-related changes that occur in each cognitive domain. Includes emphasis on contrasting the major neurodegenerative disorders related to age and describing the clinical presentation and pattern of cognitive change in each condition. Participants address current strategies for maximizing cognitive function with age and treatment strategies for the primary neurodegenerative disorders. Participants examine and identify gaps in knowledge and research approaches to fill these gaps. Explores concepts of cognitive systems, animal and imaging models, and selective pathological change with age and disease.
Intended AudiencePredoctoral and postdoctoral students from A & S, SPH, and SOM
Methods of AssessmentClass participation 30%; term paper 70%
Please see the course Session for a full list of dates and items for this course.
Academic Ethics Code
Students enrolled in the Bloomberg School of Public Health of The Johns Hopkins University assume an obligation to conduct themselves in a manner appropriate to the University's mission as an institution of higher education. A student is obligated to refrain from acts which he or she knows, or under the circumstances has reason to know, impair the academic integrity of the University. Violations of academic integrity include, but are not limited to: cheating; plagiarism; knowingly furnishing false information to any agent of the University for inclusion in the academic record; violation of the rights and welfare of animal or human subjects in research; and misconduct as a member of either School or University committees or recognized groups or organizations.
Course Location: Reed Hall 2nd Floor East Conference Room
Positron emission tomography studies of MCI and AD
Brain cutting demonstration
Imaging biomarkers and their role in diagnosis and treatment
Animal models of neurodegeneration
Genetic and environmental risk factors for cognitive decline
Genetics of cognitive disorders
CSF and blood-based biomarkers of neurodegeneration
Thursday 3:30 - 5:00 pm
Contact Information(from old syllabus)
Marilyn Albert, Ph.D.
Bryan Traynor, M.D.
Olga Pletnikova, MD
Gwenn Smith, PhD
Madhav Thambisetty, PhD
Peter Zandi, PhD, MPH
Philip Wong, PhD
Course Objectives(from old syllabus)
- Develop an understanding of biomarkers that have been examined in neurodegenerative disorders, including: imaging, cerebrospinal fluid and blood biomarkers.
- Become familiar with the genetic causes and/or risks for the major neurodegenerative diseases
- Become familiar with animal models of neurodegenerative disorders and how they can be used to examine new approaches to treatment.
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