140.688.01 | AY 2013-2014 - 4th Term | 3 Credit(s)
TTh 1:30:00 PM
  • Contact Information
  • Course Learning Objectives

    Upon successfully completing this course, students will be able to:

    • describe the basics of how microarray technology works
    • critique existing methodology for the analysis of microarray data
    • Write R code to import and analyze microarray data
  • Course Description

    Covers the basics of R software and the key capabilities of the Bioconductor project (a widely used open source and open development software project for the analysis and comprehension of data arising from high-throughput experimentation in genomics and molecular biology and rooted in the open source statistical computing environment R), including importation and preprocessing of high-throughput data from microarrays and other platforms. Also introduces statistical concepts and tools necessary to interpret and critically evaluate the bioinformatics and computational biology literature. Includes an overview of of preprocessing and normalization, statistical inference, multiple comparison corrections, Bayesian Inference in the context of multiple comparisons, clustering, and classification/machine learning.

  • Intended Audience

    Departmental; campus-wide (molecular biology/genetics researchers)

  • Methods of Assessment

    Grading Policy: Student evaluation is based on data analysis homework assignments and a final project. Students who want to learn the concepts without programming may take the class pass/fail and perform a literature review for a final project.

    Grading Restrictions: Letter grade

  • Academic Ethics Code

    The code, discussed in the Policy and Procedure Memorandum for Students, March 31, 2002, will be adhered to in this class:

    Students enrolled in the Bloomberg School of Public Health of The Johns Hopkins University assume an obligation to conduct themselves in a manner appropriate to the University's mission as an institution of higher education. A student is obligated to refrain from acts which he or she knows, or under the circumstances has reason to know, impair the academic integrity of the University. Violations of academic integrity include, but are not limited to: cheating; plagiarism; knowingly furnishing false information to any agent of the University for inclusion in the academic record; violation of the rights and welfare of animal or human subjects in research; and misconduct as a member of either School or University committees or recognized groups or organizations.

  • Disability Support Services

    If you are a student with a documented disability who requires an academic accommodation, please contact Betty H. Addison in the Office of Student Life Services:, 410-955-3034, or 2017 E. Monument Street.