223.689.01 | AY 2013-2014 - 4th Term | 3 Credit(s)
MW 3:30:00 PM
  • Contact Information
    Anna Durbin
    Jay Bream
  • Course Learning Objectives

    Upon successfully completing this course, students will be able to:

    • Identify and describe the biological obstacles preventing development of effective vaccines for several important human pathogens
    • Identify, analyze, and critique cutting-edge strategies for approaching these obstacles
    • Describe several molecular mechanisms by which various adjuvants may potentiate vaccine induced immune responses
    • Identify and explain multiple differences between the natural immune response to pathogens and the vaccine induced immune response to targeted antigens
    • Analyze and explain the implications for bio-defense of vaccine related work on various pathogens
    • Describe the advantages and disadvantages of several viral and bacterial vectors for the delivery of recombinant vacine antigens or DNA
    • Discuss the three signals necessary to trigger a primary immune response to a candidate vaccine antigen
    • Discuss the important role that vaccine type (ie live vs killed vs subunit) and route of administration (IM vs ID) can play in determining the types of immune responses elicited by immunization
  • Course Description
    Provides an overview of the biologic basis for development and evaluation of new viral, bacteriologic, parasitic, and cancer vaccines. Lectures address the fundamental immunologic concepts of correlates of protective immunity underlying current and new strategies for immunization. Emphasizes the use of new technologies for expression of vaccine antigens, including recombinant DNA techniques and use of novel adjuvants and antigen-carrier systems to enhance the delivery/presentation of specific immunogens to effector sites.
  • Methods of Assessment
    Student evaluation based on mid-term and final exams.
  • Prerequisites
    260.611-612, or equivalent knowledge of principles of modern immunology

    Additional Faculty Notes:

    Although various immunology concepts will be a recurrent theme, a detailed background in immunology is not a prerequisite for this course.  We will cover some basic immunology in the first lecture.  

  • Required Text(s)

    Additional Faculty Notes:

    No required text.

  • Course Schedule

    Please see the course Session for a full list of dates and items for this course.

  • Files from the Online Library
  • Academic Ethics Code

    Students enrolled in the Bloomberg School of Public Health of The Johns Hopkins University assume an obligation to conduct themselves in a manner appropriate to the University's mission as an institution of higher education. A student is obligated to refrain from acts which he or she knows, or under the circumstances has reason to know, impair the academic integrity of the University. Violations of academic integrity include, but are not limited to: cheating; plagiarism; knowingly furnishing false information to any agent of the University for inclusion in the academic record; violation of the rights and welfare of animal or human subjects in research; and misconduct as a member of either School or University committees or recognized groups or organizations.

  • Welcome Message

    Welcome to the CoursePlus Web site for BIOLOGIC BASIS OF VACCINE DEVELOPMENT (223.689.01), a course offered jointly by the Departments of International Health and Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health.

  • Contact Information

    Anna Durbin
    Office: HH 251
    Tel: 4-4736

    Jay Bream
    Office: E5624
    Tel: 410-502-2511

    Amanda Driscoll (Teaching Assistant)
    Office: IVAC - 855 N. Wolfe St, Ste. 600 (Rangos Bldg)
    Tel: 410-502-5823

  • Disability Support Services
    If you are a student with a documented disability who requires an academic accommodation, please contact the Office of Student Life Services at 410-955-3034 or via email at