BIOLOGIC BASIS OF VACCINE DEVELOPMENT Syllabus
Course Learning Objectives
Upon successfully completing this course, students will be able to:
- Identify and describe the biological obstacles preventing development of effective vaccines for several important human pathogens
- Identify, analyze, and critique cutting-edge strategies for approaching these obstacles
- Describe several molecular mechanisms by which various adjuvants may potentiate vaccine induced immune responses
- Identify and explain multiple differences between the natural immune response to pathogens and the vaccine induced immune response to targeted antigens
- Analyze and explain the implications for bio-defense of vaccine related work on various pathogens
- Describe the advantages and disadvantages of several viral and bacterial vectors for the delivery of recombinant vacine antigens or DNA
- Discuss the three signals necessary to trigger a primary immune response to a candidate vaccine antigen
- Discuss the important role that vaccine type (ie live vs killed vs subunit) and route of administration (IM vs ID) can play in determining the types of immune responses elicited by immunization
Provides an overview of the biologic basis for development and evaluation of new viral, bacteriologic, parasitic, and cancer vaccines. Lectures address the fundamental immunologic concepts of correlates of protective immunity underlying current and new strategies for immunization. Emphasizes the use of new technologies for expression of vaccine antigens, including recombinant DNA techniques and use of novel adjuvants and antigen-carrier systems to enhance the delivery/presentation of specific immunogens to effector sites.
Methods of Assessment
Grading Policy: Student evaluation based on mid-term and final exams.
Grading Restrictions: Letter grade
260.611-612, or equivalent knowledge of principles of modern immunology
Academic Ethics Code
The code, discussed in the Policy and Procedure Memorandum for Students, March 31, 2002, will be adhered to in this class:
Students enrolled in the Bloomberg School of Public Health of The Johns Hopkins University assume an obligation to conduct themselves in a manner appropriate to the University's mission as an institution of higher education. A student is obligated to refrain from acts which he or she knows, or under the circumstances has reason to know, impair the academic integrity of the University. Violations of academic integrity include, but are not limited to: cheating; plagiarism; knowingly furnishing false information to any agent of the University for inclusion in the academic record; violation of the rights and welfare of animal or human subjects in research; and misconduct as a member of either School or University committees or recognized groups or organizations.
Disability Support Services
If you are a student with a documented disability who requires an academic accommodation, please contact Betty H. Addison in the Office of Student Life Services: email@example.com, 410-955-3034, or 2017 E. Monument Street.