187.620.01 | AY 2013-2014 - 4th Term | 4 Credit(s)
WF 3:00:00 PM
  • Contact Information
  • Course Learning Objectives
    At the end of this course, you will be able to: - Describe the mechanism of toxicity behind multiple case examples. - In the context of these case examples: you will become familiar with normal histology of the heart, lung, ovary, testes, brain, spinal cord, lymph nodes, spleen, bone marrow, pancreas, liver and GI tract. - Describe basic histopathological lesions associated with case examples in cardiovascular, pulmonary, reproductive, neurological, immune, and gastrointestinal systems. -perform an animal necropsy.
  • Course Description

    Focuses on pathophysiology and pathologic responses of toxicity induced by toxins of the cardiovascular, pulmonary, reproductive, neurological, immune, and gastrointestinal systems. A review of normal histology for the specific organ systems is compared to examples of acute and chronic toxicity to illustrate light microscopic and ultrastructural damage with correlation to altered physiology and function. The course integrates into each organ system studied a review of standard techniques used in toxicity studies including the use of animal necropsy, histology/pathology, various tissue molecular biological techniques, transgenic mice, and noninvasive physiological monitoring.

  • Intended Audience

    EHS, Biochemistry in JHSPH; Pathobiology, Pharmacology in SOM

  • Methods of Assessment

    Grading Policy: Class participation (10%), take - home short - answer midterm (40%) and in - class short - answer final examination (50%).

    Grading Restrictions: Letter grade

  • Prerequisites


  • Academic Ethics Code

    The code, discussed in the Policy and Procedure Memorandum for Students, March 31, 2002, will be adhered to in this class:

    Students enrolled in the Bloomberg School of Public Health of The Johns Hopkins University assume an obligation to conduct themselves in a manner appropriate to the University's mission as an institution of higher education. A student is obligated to refrain from acts which he or she knows, or under the circumstances has reason to know, impair the academic integrity of the University. Violations of academic integrity include, but are not limited to: cheating; plagiarism; knowingly furnishing false information to any agent of the University for inclusion in the academic record; violation of the rights and welfare of animal or human subjects in research; and misconduct as a member of either School or University committees or recognized groups or organizations.

  • Disability Support Services

    If you are a student with a documented disability who requires an academic accommodation, please contact Betty H. Addison in the Office of Student Life Services: baddison@jhsph.edu, 410-955-3034, or 2017 E. Monument Street.