260.608.01 | AY 2013-2014 - 4th Term | 4 Credit(s)
  • Contact Information
  • Course Learning Objectives
    Upon successfully completing this course, students will be able to: • define points of the viral lifecycle at which host proteins interfere with viral infection • understand replication cycle of HIV and contrasts with other retroviruses • assess current vaccine strategies • analyze current literature • explain the influence of host factors on disease outcome
  • Course Description

    Introduces students to the HIV lifecycle and the molecular events occurring during productive infection. Covers topics including the HIV life cycle (Entry, Reverse transcription, Integration, Assembly, Budding, and Maturation), viral regulatory proteins, host innate anti-HIV responses (Apobec and Trim5á), immune responses induced by vaccine and infection, recent progress in HIV vaccine development, origins of HIV, SIV, endogenous retroviruses, new insights in HIV pathogenesis, host factors influencing disease outcome, latency and persistence, transmission, and prophylactic strategies of prevention.

  • Intended Audience

    SOM, SPH (all departments).

  • Methods of Assessment

    Grading Policy: Evaluation is based on class participation, core discussion, and a final exam.

    Grading Restrictions: Letter grade

  • Prerequisites

    PH 260.623 or instructor consent

  • Academic Ethics Code

    The code, discussed in the Policy and Procedure Memorandum for Students, March 31, 2002, will be adhered to in this class:

    Students enrolled in the Bloomberg School of Public Health of The Johns Hopkins University assume an obligation to conduct themselves in a manner appropriate to the University's mission as an institution of higher education. A student is obligated to refrain from acts which he or she knows, or under the circumstances has reason to know, impair the academic integrity of the University. Violations of academic integrity include, but are not limited to: cheating; plagiarism; knowingly furnishing false information to any agent of the University for inclusion in the academic record; violation of the rights and welfare of animal or human subjects in research; and misconduct as a member of either School or University committees or recognized groups or organizations.

  • Disability Support Services

    If you are a student with a documented disability who requires an academic accommodation, please contact Betty H. Addison in the Office of Student Life Services:, 410-955-3034, or 2017 E. Monument Street.