Course Learning Objectives
Upon successfully completing this course, students will be able to:
- Discuss the complex relationships between host and vector that affect transmission and control
- Integrate the host and parasite relationships to Discuss the immune response, nature of disease, and disease manifestations
- Interpret epidemiological indices associated with patterns of malaria transmission
- Evaluate different approaches to malaria control through vector control, chemotherapy, and vaccines when they become available
- Describe the differences between the various species of Plasmodium affecting humans
Course DescriptionPresents issues related to malaria as a major public health problem. Emphasizes the biology of malaria parasites and factors affecting their transmission to humans by anopheline vectors. Topics include host-parasite-vector relationships; diagnostics; parasite biology; vector biology; epidemiology; host immunity; risk factors associated with infection, human behavior, chemotherapy, and drug resistances; anti-vector measures; vaccine development; and management and policy issues.
Methods of Assessment
Student evaluation based on take-home mid-term and final exams.
Additional Faculty Notes:
The midterm is a take home exam covering the first 8 lectures to be turned in on November 26th at 1:30, a Tuesday. The midterm will be released on November 19.
The final will be a take home exam test on all concepts covered in the course weighted for the last 7 lectures. The final will be released on Dec 12 and will be due Dec 19 at 1:30 pm.
The midterm and final will each count 50% of the grade.
Additional Faculty Notes:
Suggested but not required textbooks:
Essential Malariology Edited by David A. Warrell and Herbert M. Gilles
Malaria Molecular and Clinical Aspects Edited by Mats Wahlgren and Peter Perlmann
Malaria: Drugs, Disease and Post-genomic Biology Edited by D.J. Sullivan and S. Krishna
Textbooks are available at library or online bookstores new or used.
Please see the course Session for a full list of dates and items for this course.
Oct 29 Shiff/ Sullivan Overview and Biology of Parasite Oct 31 Shiff Malaria epidemiology Nov 5 Sinnis Pre erythrocyte biology Dinglasan Biology of gametocytes Nov 7 Ockenhouse, Chris MVI Immunopathogenesis Nov 12 Sullivan Malaria diagnosis and laboratory Nov 14 Zavala Immunity to malaria Nov 19 Hall, LEE NIAID Malaria Vaccines Nov 21 Norris Malaria Entomology Nov 26 Harvey Behavior change interventions for malaria control Dimopoulos Genomic Analyses of Anopheles-Plasmodium Interactions Nov 28 Thanksgiving Holiday Dec 3 Shiff Malaria control Dec 5 Sullivan Malaria Chemotherapy Shiff Elimination Strategies-past and present Dec 10 Sullivan Drugs for Malaria control Prigge Targets for new drugs Dec 12 Jacobs Lorena Genetic approaches malaria control Smith Modeling elimination Dec 17 Nyunt Malaria in Pregnancy/HIV Sullivan Drug pharmacokinetics and dynamics Dec 19 Plowe, Chris U Maryland Drug resistance and Pop genetics
Academic Ethics Code
The code, discussed in the Policy and Procedure Memorandum for Students, March 31, 2002, will be adhered to in this class:
Students enrolled in the Bloomberg School of Public Health of The Johns Hopkins University assume an obligation to conduct themselves in a manner appropriate to the University's mission as an institution of higher education. A student is obligated to refrain from acts which he or she knows, or under the circumstances has reason to know, impair the academic integrity of the University. Violations of academic integrity include, but are not limited to: cheating; plagiarism; knowingly furnishing false information to any agent of the University for inclusion in the academic record; violation of the rights and welfare of animal or human subjects in research; and misconduct as a member of either School or University committees or recognized groups or organizations.
Welcome to MALARIOLOGY (260.656.01) an advanced course for people interested in a broad up-todate picture of malaria, the disease, its transmission, its biology and control. It is presented by faculty in MMI and guest experts.
Room W4019 Tuesday and Thursday from 1:30 to 3:20 PM.
Overview and Biology of Parasite; Chemotherapy; Immunopathogenesis; Drug resistance and Pop genetics; Malaria epidemiology; Immunity to malaria; Malaria Vaccines; Malaria diagnosis; Targets for new drugs; Malaria in Pregnancy/HIV; Behavior change interventions for malria control; Malaria Entomology and Insecticide resistance; Mosquito population biology; Genomic Analyses of Anopheles-Plasmodium Interactions; Modeling Malaria control; GIS and malaria risk factors; Malaria Eliminition and the Research Agenda
David Sullivan, MD
Office: E5628 BSPH
Tel: 410 502 2522
Home Page: http://faculty.jhsph.edu/Default.cfm?faculty_id=681
Upon completion of this course students will • Understand the complex relationships between host and vector that affect transmission and control. • Integrate the host and parasite relationships to understand the immune response, nature of disease and disease manifestations. • Interpret epidemiological indices associated with patterns of malaria transmission. • Evaluate different approaches to malaria control, either through vector control, chemotherapy and vaccines when they become available. • Understand the differences between the various species of Plasmodium affecting humans.
Disability Support ServicesIf you are a student with a documented disability who requires an academic accommodation, please contact Betty H. Addison in the Office of Student Life Services: firstname.lastname@example.org, 410-955-3034, or 2017 E. Monument Street.