GENOME INTEGRITY AND CANCER Syllabus
Course Learning Objectives
This course will prepare you to be able to do the following:
- Understand how exposure to various environmental agents and anti-cancer drugs can lead to modifications of DNA
- Understand the mechanisms by which DNA repair proteins and enzymes maintain the integrity of the genome
- Understand how DNA protection and repair systems function in the context of the cell
- Understand the connections between DNA damage/DNA repair capacity and human disease, particularly cancer
- This is a Masters/PhD course designed to give the student mastery of the molecular mechanisms that maintain the integrity of DNA structure and information content. The course is taught through lectures, each of which focuses on a particular topic regarding repair of DNA damage. Students will learn about chemical reactions that result in DNA damage, enzyme mechanisms and protein structures of DNA damage repair systems, and how DNA protection and repair systems function in the context of the cell. The course will emphasize connections between DNA damage and human disease, particularly cancer.
Course DescriptionExamines molecular mechanisms devoted to the preservation of genome integrity in eukaryotic cells. Topics include DNA damage recognition, DNA repair pathways, cell cycle checkpoint mechanisms, the role of p53 in DNA damage responses, the role of ubiquitination and sumoylation in DNA repair, telomere maintenance and DNA repair proteins as targets for therapeutic intervention. Emphasizes the relevance of these mechanisms to human cancer.
Intended AudienceMHS and PhD students interested in the biomedical sciences
Methods of AssessmentTwo in-class exams.
PrerequisitesGraduate level molecular biology, and biochemistry or the equivalent.
Please see the course Session for a full list of dates and items for this course.
Academic Ethics Code
Students enrolled in the Bloomberg School of Public Health of The Johns Hopkins University assume an obligation to conduct themselves in a manner appropriate to the University's mission as an institution of higher education. A student is obligated to refrain from acts which he or she knows, or under the circumstances has reason to know, impair the academic integrity of the University. Violations of academic integrity include, but are not limited to: cheating; plagiarism; knowingly furnishing false information to any agent of the University for inclusion in the academic record; violation of the rights and welfare of animal or human subjects in research; and misconduct as a member of either School or University committees or recognized groups or organizations.
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