330.619.01 | AY 2013-2014 - 4th Term | 3 Credit(s)
MW 10:30:00 AM
  • Contact Information
  • Course Learning Objectives

    After completing this course, you should be able to:

    • Analyze data from genome-wide or candidate methylation studies
    • Perform Systems-Based and Polygenic Analyses from Genome-wide Association Data
    • Perform Genetic Association Studies Using Data Generated Next Generation Sequencing
    • Perform Power Calculations for Genetic Association Studies
    • Apply Simulation-based Approaches to Calculate Statistical Power or Emipirical Significance to Genetic Studies
  • Course Description

    Addresses the rapidly changing landscape of the study of complex genetics diseases. Students explore the current state of the quantitative issues in complex disease genetics, so that they can translate their experiences into research practice. Analyzes genome-wide association scans, epigenetics, and next-generation sequencing, as well as approaches to power calculation, including the use of simulation. Students study the current literature as well as examples from real data sets. In addition to learning the analytic techniques, students also become familiar with the assumptions and limitations of these approaches.

  • Intended Audience

    Students interested in applying novel genetic analytic techniques to complex diseases.

  • Methods of Assessment

    Grading Policy: Exams and a Project

    Grading Restrictions: Letter grade

  • Academic Ethics Code

    The code, discussed in the Policy and Procedure Memorandum for Students, March 31, 2002, will be adhered to in this class:

    Students enrolled in the Bloomberg School of Public Health of The Johns Hopkins University assume an obligation to conduct themselves in a manner appropriate to the University's mission as an institution of higher education. A student is obligated to refrain from acts which he or she knows, or under the circumstances has reason to know, impair the academic integrity of the University. Violations of academic integrity include, but are not limited to: cheating; plagiarism; knowingly furnishing false information to any agent of the University for inclusion in the academic record; violation of the rights and welfare of animal or human subjects in research; and misconduct as a member of either School or University committees or recognized groups or organizations.

  • Disability Support Services

    If you are a student with a documented disability who requires an academic accommodation, please contact Betty H. Addison in the Office of Student Life Services:, 410-955-3034, or 2017 E. Monument Street.